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Archived from the original on Plaviix December Ranitidine, famotidine Pepcidand antacids are not expected to interfere with the anti-clotting activity of Plavix. A: According to drug information, Plavix is prescribed to reduce the rate of atherothrombotic events such as heart Plavlx. Raising HDL PPlavix cholesterol appears to be equally important. For more specific information, consult with Poavix doctor or local pharmacist for guidance based on your specific condition and current medications. In addition to the uses listed above, Plavix may be used off-label. Stents are usually placed when someone has a blockage in their artery that is stopping blood from flowing through the artery. Not all possible drug interactions are listed here. Tell your doctor if you develop an allergic reaction including skin reactions while taking Plavix. If you're concerned that you or someone else might have overdosed, get to the emergency room right away or call a poison control center at Medication information offered on this site is for informational purposes only and is neither independently verified nor endorsed by Everyday Health, Inc. Archived from the original on 23 February The trial's primary outcome was the time to first occurrence of new ischemic Plavkx fatal or notnew myocardial Plqvix Plavix or notor other vascular death. Plavix may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Other people were given a placebo treatment with no active drug with aspirin. A: Plavix clopidogrel hinders the platelets in the blood from coagulating clotting to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Who should not take Plavix? Store it at room temperature and away from excess heat and moisture not in the bathroom. Plavix may not work as well in people who: have certain genetic factors that affect how the body breaks down Plavix. The generic is considered to be as safe and effective as the original drug. The combination of Plavix and aspirin can increase the risk of further bleeding. This drug should work safely and effectively for you regardless of your specific diet. Letter from the Editor: The importance of accurate reporting. Drug Label Information Updated May 17, If you are a consumer or patient please visit this version. Do not stop any medication or change the dose without first talking to your provider. Bristol-Myers Squibb. This is because certain antidepressants and Plavix can each increase your risk of bleeding. Is there anything I can do to reverse my situation? Clopidogrel use during labor or delivery will increase the risk of maternal bleeding and hemorrhage. This is not a complete list of side effects associated with Plavix. If you have any bleeding that seems to last too long, or if you have any blood in your stool or urine, call your doctor right away. Should I continue or is it enough? A: When a patient has a stent placed in the body, which is a wire mesh placed in the blood vessel wall, it takes time for the lining of the blood vessel to grow over the top of that wire mesh. Sometimes, Plavix is prescribed to help prevent blood clots from forming in people who have both atrial fibrillation and acute coronary syndrome. Your pharmacist will be able to recommend a suitable indigestion remedy for you.

Plavix - have hit

Pharmacodynamic and Plafix interactions connected in these medications showed that the movement was shortest with omeprazole and least with dexlansoprazole. View Explanation Photos. The cumin incidence of bleeding is classified in Table 1. Clopidogrel doesn't have any type of health, including Plavid combined pill and identity contraception. In order for Plavix to work in Plavic body, Plavix medication needs to be used Pkavix the body to the most form. Something, at high doses in vitroclopidogrel undergoes CYP2C9. Drug Metab. Back to Thousands A to Z. A kid drug is an exact copy of a brand-name drugstore. Ask your night or check the Beta Guide for a list of the old. Plavix is used to decorate blood clots in patients after a heart attack or partial or in those times with disorders of the heart or blood vessels. What if I take too much. The mona of warnings or other health for a given drug does not receive that the drug or drug toxicity is safe, nancy, or appropriate for all substances or all why uses. Many cleaner know the perimeter signs of a diagnosis, such as facial crashing, muse flip, and other speaking. These are not all the side effects of clopidogrel. Is Plavix any food or drink I need to avoid? Food and Drug Administration FDA announced that clopidogrel should be used with caution in people using the proton-pump inhibitors omeprazole or esomeprazole[26] [27] but pantoprazole appears to be safe. All rights reserved. Any thoughts or suggestions? Will I need to stop clopidogrel before surgery or dental treatment? In addition, over-the-counter aspirin is used to prevent heart attack in people who have had a heart attack or who experience angina; and it is used in the treatment of a heart attack. Get medical help right away if you have any of these symptoms and they can not be explained by another Palvix condition: Plzvix spots called purpura on the skin or in the mouth mucous membranes due to bleeding under the skin your skin or the Plagix of Plavix eyes Plaivx yellow jaundice you feel tired or weak your skin looks very pale fever fast heart rate or feeling short of breath headache speech changes confusion coma lPavix seizure low amount Plaix urine, or urine that is pink or has blood in it stomach area abdominal pain nausea, vomiting, or diarrhea vision changes persistent low blood sugar symptoms Tell your doctor if you have any side effect that bothers you or that does not go away. This results in less blood flow to certain areas of your body, such as your arms and legs. Do not stop taking clopidogrel without talking to your doctor. How Supplied: Tabs 75mg—30, 90,; mg— The effectiveness of Plavix results from its antiplatelet activity, which is dependent on its conversion to an active metabolite by the cytochrome P CYP system, principally CYP2C19 [see Warnings and Precautions 5. They should talk to the doctor who prescribed Plavix for you before you have any surgery or invasive procedure. Quit smoking - smoking increases your heart rate and blood pressure. Clopidogrel has also been shown to be effective at decreasing platelet aggregation in cats, so its use in prevention of feline aortic thromboembolism has been advocated. Tell your doctor about all the medicines you takeincluding prescription, non-prescription medicines, vitamins and herbal supplements. It appears that other medications for acid reduction such as Zantac ranitidinePepcid famotidine etc. Plavix contains the active drug clopidogrel. However, another class of acid reducers, the proton pump inhibitors PPIsshould be avoided with Plavix. Subsequent metabolism of Palvix 2-oxo-clopidogrel intermediate metabolite results in formation of the active metabolite, a thiol derivative of clopidogrel. It is also used, along with acetylsalicylic acid ASA, aspirinfor the Plafix of thrombosis after placement of a coronary stent [14] or as an alternative antiplatelet drug Plavxi people intolerant to aspirin. Drugs can cause Pllavix gain in several different ways. Read this Medication Guide before Plafix start taking Plavix and each time you get a refill. No other difference in the rate of adverse events other than bleeding was reported. Overdose can cause excessive bleeding. What should I do if I forget a dose? Clopidogrel is one of the drugs metabolized by this enzyme. An example of a PPI is omeprazole Prilosec. Arch Intern Med. A: Both lisinopril and Keppra can cause you to have a tired feeling. Do not take a double dose to make up for a missed one. Plavix does not come in generic form in the United States at this time. In my experience, most doctors don't know that about 30 percent of Caucasians, 40 percent of African Americans and more than 55 percent of East Asians have an underperforming version of the liver enzyme that's needed to metabolize Plavix and many other drugs. Do not stop or change the amount of medication you take without talking to your health care provider first. Hemorrhages, including those with fatal outcome, have been reported in patients treated with Plavix. Like all medicines, clopidogrel can cause side effects, although not everyone gets them. Plvix this study, 2. Food and Drug Administration FDA added a boxed warning to Plavix alerting that the drug can be less effective in people Plavix to metabolize the drug to convert it to its active form. Tell your doctor if you're taking these medicines before you start taking clopidogrel: medicines to thin blood or prevent blood Pavix, such as aspirinPlavxirivaroxaban or apixaban non-steroidal anti-inflammatory drugs NSAIDssuch as ibuprofen antidepressants called selective serotonin reuptake inhibitors SSRIssuch as citalopram indigestion medicines called proton pump inhibitors PPIssuch as omeprazole Taking clopidogrel with everyday painkillers Your doctor may prescribe daily low dose aspirin 75mg tablets to take together with clopidogrel. Platelet aggregation inhibitors. List of brand names. Archived from the original on 1 April Although the administration of clopidogrel 75 mg per day did not modify the pharmacokinetics of S-warfarin a CYP2C9 substrate or INR in patients receiving long-term warfarin therapy, coadministration of Plavix with warfarin increases the risk of bleeding because of independent effects on hemostasis. Grapefruit juice may increase the blood-thinning effect of your medicine. Your doctor will determine the best dosage to suit your needs. Plavix is also indicated to reduce the rate of myocardial infarction or stroke in people with recent myocardial infarction, recent stroke, or established peripheral artery disease PAD. Do not stop taking Plavix without talking to the doctor who prescribes it for you.
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Plavix
(Active Ingredient: Clopidogrel)
Plavix is used for reducing the risk of stroke or heart attack in patients who have already had a heart attack or stroke, have other circulatory problems caused by narrowing and hardening of the arteries, or have certain other heart problems (eg, unstable angina).
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  • INDICATIONS

    Plavix is used for reducing the risk of stroke or heart attack in patients who have already had a heart attack or stroke, have other circulatory problems caused by narrowing and hardening of the arteries, or have certain other heart problems (eg, unstable angina). Plavix is a platelet aggregation inhibitor. It works by slowing or stopping platelets from sticking to blood vessel walls or injured tissues.

    INSTRUCTIONS

    Use Plavix as directed by your doctor.

    • Take Plavix by mouth with or without food.
    • If you miss a dose of Plavix, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

    Ask your health care provider any questions you may have about how to use Plavix.

    STORAGE

    Store Plavix at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Plavix out of the reach of children and away from pets.

    MORE INFO:

    Active Ingredient: Clopidogrel bisulfate.

  • Do NOT use Plavix if:

    • you are allergic to any ingredient in Plavix
    • you have an active bleeding disorder, such as a stomach ulcer or bleeding in the brain
    • you are taking certain azole antifungals (eg, fluconazole, ketoconazole, voriconazole), cimetidine, etravirine, felbamate, fluoxetine, fluvoxamine, certain proton pump inhibitors (eg, omeprazole, esomeprazole), or ticlopidine.

    Contact your doctor or health care provider right away if any of these apply to you.

    Some medical conditions may interact with Plavix. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    • if you are pregnant, planning to become pregnant, or are breast-feeding
    • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    • if you have allergies to medicines, foods, or other substances
    • if you have bone marrow disease, liver or kidney problems, or a history of ulcers
    • if you have had a recent injury or surgery, including dental surgery.

    Some medicines may interact with Plavix. Tell your health care provider if you are taking any other medicines, especially any of the following:

    • Dabigatran, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral anticoagulants (eg, warfarin), or salicylates (eg, aspirin) because the risk of bleeding may be increased by Plavix
    • Azole antifungals (eg, ketoconazole), cimetidine, etravirine, felbamate, fluoxetine, fluvoxamine, proton pump inhibitors (eg, omeprazole), or ticlopidine because they may decrease Plavix's effectiveness
    • Fluvastatin, phenytoin, tamoxifen, tolbutamide, or torsemide because the risk of their side effects may be increased by Plavix.

    This may not be a complete list of all interactions that may occur. Ask your health care provider if Plavix may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

    Important safety information:

    • Plavix may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Plavix with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
    • Plavix may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
    • Tell your doctor or dentist that you take Plavix before you receive any medical or dental care, emergency care, or surgery. You may need to stop Plavix before you have certain types of surgery.
    • Plavix must be converted in the body for it to work. This conversion does not occur as well in some people (about 2% of white patients, 4% of black patients, and 14% of Chinese patients). The medicine may not work as well in these patients. Your doctor may perform a test to check how well your body is able to convert Plavix. Talk with your doctor for more information.
    • Plavix should not be used in children; safety and effectiveness in children have not been confirmed.
    • Pregnancy and breast-feeding: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Plavix while you are pregnant. It is not known if Plavix is found in breast milk. Do not breastfeed while taking Plavix.
  • All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Easy bruising; minor bleeding.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding in the eye; change in the amount of urine produced; change in vision; chest pain; dark or bloody urine; fever or sore throat; loss of appetite; pale skin; seizures; severe, persistent headache; speech problems; unexplained weight loss; unusual bruising or bleeding; unusual or severe bleeding (eg, excessive bleeding from cuts, increased menstrual bleeding, unexplained vaginal bleeding, unusual bleeding from the gums when brushing); unusual tiredness or weakness; yellowing of the skin or eyes.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.